Hey buddy...
You could write a book about this single topic.
Isonychia nymphs are readily available to trout from late May through Mid October on most of our trout streams in the Northeast.
These nymphs are very fast and erratic swimmers. They are also larger than most mayflies with the exception of the larger and more notable Green and Brown Drakes. These flies used to have several sub-species now they are all classified as Isonychia Bi-color. The nymphs are charachterized by their three short stubby but prominent tails. They also have very easily recognizable gills along their sides and are a charcoal/olive color. They look like very sleek swimming machines, which, in reality is what they are.
Since this hatch is so long in duration trout get great opportunity to get used to feeding on these insects. You would not call this a "super" hatch because the hatch intensity on most streams in the region is not high. However, the nymph density is very high. These nymphs inhabit faster boulder strewn water which is found on streams such as, the Housatonic, Beaverkill and the Lower West Branch of the Delaware as well as the Lehigh River in Pennsylvania. These are four streams that in my opinion have some of the best Iso hatches in the region.
I have been told byh my friend Tony that he sees tons of immature Isonychia nymphs in the months of February and March when he is sampling for insects. However,, at this time of the year I find stoneflies, scuds, small caddis larvae and aquatic worms to be more effective for catching trout during the late winter. This would indicate that even though behavioral drift is occurring with these flies they are not of importance as far as trout food is concerned at this time of year.
I start to use Iso nymphs when I go to the river and see their nymphal shucks on the rocks. This is a mayfly that migrates to the side of the stream to hatch. You need not even see the adults to know that they are hatching. All you need to do is check out the rocks prior to wetting a line and look for the shucks. This a time of the year when I get really excited. I know that I am in the game on any stream that I choose to fish as long as I have something that represents an Isonychia tied to the end of my tippet.
There are many different immitations that you can use to catch trout sub-surface during this hatch. My favorite is to use a nymph that closely immitates the naturals. The nymphs that I use can range from a Prince nymph which would be considered impressionistic to a very realistic immitation such as a Rob's Realistic Iso nymph. When fishing on heavily pressured streams like the Delaware, I like to use nymphs that very closely "match the hatch". On rivers like the Housatonic, where the trout are more opportunistic, I find that a simple prince nymph or a zug bug works wonders on the trout. Don't get me wrong there are times when you need to use a more relistic nymph when fishing on less pressured water.
I have also found that fishing wet flies during this hatch can be quire effective as well. Since the nymphs are fast swimmers swinging three wet flies through the riffles can yield fish that would not touch even the best iso nymph imitations. I found swinging wet flies to be ultra-productive on the South Branch of the Raritan. The wet flies that worked the best were the Picket Pin and the Leadwing coachman. When the trout would slash at the surface for the emerging adults I would swing the flies over the trout and and more often than not this would draw some viscious strikes.
When I rig my line for this hatch I use my standard nymph rig. I tie on my larger Isonychia nymph and trail it with something smaller like a rs2 or a wd40. Usually when the Isonychia are hatching you can be very sure that there are BWOs hatching at the same time as well.
I use a fair amount of weight so that I am right on the bottom because these nymphs inhabit such fast water and I think the trout really key on the nymphs that just come off the bottom to hatch or get washed off the rocks in the swift current.
When I fish wet flies during this hatch I use the Joe Humphries wet fly leader. I tie the first two wet flies on 3X droppers. I feel that the size of the tippet has little effect on whether or not the trout are going to take your offering. Most of the time I do not use weight when I am fishing with wet flies. However, there are times when I do feel the need to use weight, especially in the deeper and faster runs.
I hope that these tips/suggestions might shed some light on how and why to fish Isonychia nymphs.